Even in otherwise healthy older people, it has been found that the intestinal barrier function declines and bacterial toxins are transmitted more readily. These toxins can cause inflammation, which in turn can contribute to cardiovascular disease, metabolic fatty liver disease, type II diabetes and even neurological disorders.
Previous research has suggested that a diet high in sugar, and fructose in particular, can compromise the integrity of the intestinal barrier. The results of previously unpublished studies in mice suggest that, contrary to the findings in young animals, the intake of small amounts of fructose improves the integrity of the intestinal barrier.
Specifically, the following research questions are the focus of attention:
- How does the intake of small amounts of free sugar (fructose) affect the intestinal barrier function and immune response of older people?
- And to what extent is this related to quality of life?
